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Because of the potential reversible nature of ALD with sobriety, regular screening of the general population and early diagnosis are essential.Īlcohol is a hepatotoxin that is commonly consumed worldwide and is associated with a spectrum of liver injury including simple steatosis or fatty liver, alcoholic hepatitis, fibrosis, and cirrhosis. The histological features of ALD can ultimately define the diagnosis according to the typical presence and distribution of hepatic steatosis, inflammation, and Mallory-Denk bodies. In unclear cases, the diagnosis can be supported by imaging and liver biopsy.

Typical laboratory findings in ALD include transaminase levels with aspartate aminotransferase greater than alanine aminotransferase as well as increased mean corpuscular volume, gamma-glutamyltranspeptidase, and IgA to IgG ratio. In addition, clinical findings may be absent or minimal in early ALD characterized by hepatic steatosis. However, the diagnosis of ALD can be clinically challenging as there is no single diagnostic test that confirms the diagnosis and patients may not be forthcoming about their degree of alcohol consumption. The diagnosis of ALD can generally be made based on history, clinical and laboratory findings. All patients who present with clinical features of hepatitis or chronic liver disease or who have elevated serum elevated transaminase levels should be screened for an alcohol use disorder. Excessive or harmful alcohol use is ranked as one of the top five risk factors for death and disability globally and results in 2.5 million deaths and 69.4 million annual disability adjusted life years. Alcoholic liver disease (ALD) is a general term used to refer to this spectrum of alcohol-related liver injuries. Dapatkan info lebih lanjut dari kami dengan menghubungi email telp (021) 29018652 dengan Tim Solution Expert kami yang siap membantu Anda.Alcohol is a hepatotoxin that is commonly consumed worldwide and is associated with a spectrum of liver injury including simple steatosis or fatty liver, alcoholic hepatitis, fibrosis, and cirrhosis.
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